I-Demenidazole, njengesizukulwane sokuqala semithi yezinambuzane ze-antigenic, intengo yayo ephansi iyenza isetshenziswe kabanzi ekuxilongeni nasekwelashweni kwezilwane. Kodwa-ke, ngokusetshenziswa okubanzi kwalolu hlobo lwezidakamizwa kanye nesizukulwane esisemuva kanye nesakuqala se-nitroimidazoles, inkinga yokungazweli emthini ekusetshenzisweni izoba ngokugqama kakhulu.

01Umphumela we-Anti-anaerobic

Kodwa-ke, ukusetshenziswa kwayo okubanzi ekukhiqizeni izinkukhu kubonakala ikakhulukazi kuma-anti anaerobic bacteria. Emashumini eminyaka adlule, isetshenziswe kabanzi ekwelapheni i-necrotic enteritis yenkukhu, i-enterotoxic syndrome kanye nokuvuvukala kwe-oviduct. Kodwa-ke, ukuzwela kwayo kuma-anaerobes kuya ngokuya kuba kubi kakhulu. Isizathu siwukuthi: isikhathi eside esikhathini esidlule, ukuxhashazwa nokusetshenziswa okungajwayelekile kwayo kuye kwaholela ekwandeni kokumelana kwezinhlobo ezihlukahlukene zebhaktheriya anaerobic kuwo unyaka nonyaka, futhi ukuqapha kusaqhubeka. Ukuze kunqandwe lo mkhuba omubi wentuthuko, umnyango onekhono wezokwelapha wezilwane uye wawuvala ngokusobala eminyakeni engaphezu kweyishumi edlule: ungasetshenziswa kuphela ekuzaleni nasekukhiqizeni izilwane ezidliwayo ezisetshenziswa kakhulu, futhi zingasetshenziswa kuphela ukuzalanisa imfuyo nezinkukhu, izilwane ezifuywayo kanye nokunye okungekona ukudla okukhethekile.

02Ukuhambisana kwesayensi nokunengqondo

Esicini sokuhambisana nokusetshenziswa okungenangqondo kwe-demenidazole, okokuqala, akufanele isetshenziswe kanye ne-methamphenicol, i-florfenicol namanye ama-antibiotic e-amido alcohol, ngoba i-demenidazole ingabangela i-dysplasia yomnkantsha emfuyweni nasezinkukhuni, futhi uma isetshenziswa kanye nalokhu okungenhla. i-amido alcohol antibiotics, izokwandisa ingozi yokusabela okubi ohlelweni lwegazi.

Okwesibili, akufanele isetshenziswe nge-ethanol noma amalungiselelo aqukethe inani elikhulu le-ethanol, ngoba ukuhlanganiswa kokubili kuzodala ukusabela kwe-disulfiram, futhi izilwane ezigulayo zingase zibe nezimpawu ezithile zokuphazamiseka kwezinzwa. Ngaphezu kwalokho, ukusetshenziswa kotshwala noma izidakamizwa eziqukethe inani elikhulu lotshwala kufanele kuncishiswe ngangokunokwenzeka phakathi kwezinsuku ezingama-7-10 ngemuva kokuhoxiswa kwezidakamizwa.

Okwesithathu, ikakhulukazi embonini yezokwelapha ezifuywayo, okokuqala, akufanele kuhlanganiswe nezidakamizwa ze-immunosuppressive, ngaphandle kwalokho, i-demenidazole ingase ivimbele umphumela we-mycophenolate mofetil emzimbeni. Okwesibili, ayikwazi ukusetshenziswa nama-anticoagulants omlomo, okuzothuthukisa umphumela we-anticoagulant we-anticoagulants yomlomo njenge-warfarin, ukuze izilwane ezifuywayo zibe nengozi eyengeziwe yokopha.

Okokugcina, lokhu ikakhulukazi embonini yezokwelapha ezifuywayo. Okokuqala, ayikwazi ukuhlanganiswa nezidakamizwa ze-enzyme inhibitors zesibindi. Isibonelo, ama-enzyme ezidakamizwa zesibindi njenge-cimetidine angavimbela i-metronidazole metabolism. Uma kuhlangene, kuyadingeka ukuthola ukuhlushwa kwezidakamizwa zegazi futhi ulungise umthamo ngokushesha. Okwesibili ukuthi ayikwazi ukusetshenziswa nama-enzyme e-hepatic drug inducers. Uma kuhlanganiswa nama-enzyme ezidakamizwa ze-hepatic inducers afana ne-phenytoin, i-metabolism ye-demenidazole izosheshisa futhi ukuhlushwa kwe-plasma kuzoncipha; I-metabolism ye-phenytoin namanye ama-enzyme ezidakamizwa ze-hepatic inducers yehliswa ijubane futhi ukugxila kwe-plasma kwanda.

03Ukulungiswa kuthinta umphumela wokwelapha

Ngenxa yokuthi i-demenidazole ngokwayo iyancibilika kancane emanzini futhi iyimithi elwa namagciwane encike esikhathini, ukukhubazeka kwezidakamizwa nezici ze-pharmacodynamic kunquma ukuthi "ukulungiswa kunquma ukusebenza kahle". Sivame ukubona kumayunithi ezimpande ukuthi ukuncibilika komkhiqizo we-dimenidazole premix kubi kakhulu. Ngemva kokungeza inani elikhulu lamanzi nokuxuba ngokugcwele, kukhona "inani elikhulu lezinto ezingancibiliki" kusampula yesihlabathi esihle. Lokhu empeleni akuwona “ubuciko” bomkhiqizi ukubiza inkinga yekhwalithi yamanzi, noma ukuqamba amanga ukuthi izinto ezingancibiliki ziyizinto ezisizayo kanye nezinye izithako ezingezona izidakamizwa.

Yonke imikhiqizo enjalo exubile ye-dimenidazole, ngaphezu kweshibhile futhi eshibhile, ihlangene “ayikho imiphumela”.

Ngakho-ke, abalimi abaningi basemazingeni aphansi kanye nabasebenzisi bezidakamizwa zezilwane kufanele banake imikhiqizo "yekhwalithi ephezulu" enokuqukethwe kwezidakamizwa okwanele nokuncibilika okuhle lapho bekhetha imikhiqizo ye-dimenidazole premix yokwelapha izifo ze-anaerobic emgudwini wokugaya ukudla noma ohlelweni lokuzala. Ngaphezu kokukhethwa kwezidakamizwa, isinyathelo esibaluleke kakhulu yilesi: ngokweqiniso lenhloso yokwanda kokungazweli emishanguzweni, kufanele senze umsebenzi omuhle ekuhlanganiseni, ekuhlanganiseni nasekusebenziseni ngokubambisana kokumelana nezidakamizwa, ukuze sithuthukise futhi sibonise "ukusebenza kahle" kokwelashwa kwezidakamizwa.