I-Imidacloprid ne-Moxidectin Spot-on Solutions(yezinja)

【Isithako Esiyinhloko】

I-Imidacloprid, i-Moxidectin

【Ukubukeka】

Uketshezi oluphuzi kuya kunsundu.

【Pisenzo se-harmacologic】

Umuthi we-Antiparasite.

I-Pharmacodynamics:I-Imidacloprid isizukulwane esisha se-nicotine insecticide ene-chlorine. Inobudlelwane obuphezulu be-postsynaptic nicotinic acetylcholine receptors ohlelweni lwezinzwa oluphakathi lwezinambuzane, futhi ingavimbela umsebenzi we-acetylcholine, okuholela ekukhubazekeni kwe-parasite nokufa. Isebenza ngempumelelo ngokumelene namazeze amadala namazeze amancane ezigabeni ezihlukahlukene, futhi iphinde ibe nomphumela we-kiling kumazeze amancane endaweni ezungezile. Indlela yokusebenza ye-moxidectin ifana neye-abamectin ne-ivermectin, futhi inomphumela omuhle we-kiling kuma-parasites angaphakathi nangaphandle, ikakhulukazi ama-nematodes nama-arthropods. Ukukhululwa kwe-butyric acid(GABA) kukhulisa amandla ayo okubopha kumamukeli we-postsynaptic, futhi isiteshi se-chloride siyavuleka. I-Moxidectin iphinde ibe nokukhetha kanye nokuhambisana okuphezulu kweziteshi ze-ion ion ze-glutamate-mediated chloride, ngaleyo ndlela iphazamise ukudluliswa kwesignali ye-neuromuscular, ukuphumula nokukhubaza ama-parasite, okuholela ekufeni kwama-parasites. I-interneurons evimbelayo kanye nama-motor neurons ajabulisayo kuma-nematodes yizindawo zayo zokusebenza, kuyilapho kuma-arthropods i-neuromuscular junction. Ukuhlanganiswa kwakho kokubili kunomphumela we-synergistic.

I-Pharmacokinetics:Ngemuva kokuphathwa kokuqala, i-imidacloprid yasakazwa ngokushesha ebusweni bomzimba wenja ngalolo suku, futhi yahlala phezu komzimba ngesikhathi sokuphatha izinsuku ezingama-4-9 ngemuva kokuphathwa, ukugcwala kwe-plasma ye-moxidectin ezinjeni kufinyelela ezingeni eliphakeme kakhulu, futhi isatshalaliswa emzimbeni wonke phakathi nenyanga eyodwa bese igaywa kancane kancane bese ikhishwa.

【Izinkomba】
Ukuvimbela nokwelashwa kwezifo zangaphakathi nangaphandle ze-parasitic ezinjeni. Ukuvimbela nokwelashwa kwezinambuzane (Ctenocephalic canis), ukwelashwa kwezintwala (Catonicus canis), ukwelashwa kwe-ear mite (ltchy otica), canine sarcoids (Scabies mites), kanye ne-demodicosis (Demodex canis), ekwelapheni i-Angiostrongylus kanye izifo ze-nematode zamathumbu (abadala, ama-aduts angavuthiwe kanye ne-L4izibungu ze-Toxocara canis, i-Ancylostoma canis, kanye nezibungu ze-Ancylocephalus;abadala be-Toxocara lionis kanye ne-Trichocephala vixensis). Futhi ingasetshenziswa njengendlela yokwelapha i-adjuvant ye-allergenic dermatitis ebangelwa amazeze.

【Ukusetshenziswa nomthamo】
Ukusetshenziswa kwangaphandle, phonsa lo mkhiqizo esikhumbeni kusukela ngemuva kwenja phakathi kwamahlombe amabili kuya ezinqeni, futhi uwuhlukanise ezindaweni ezingu-3-4. Umthamo owodwa, wezinja, nge-1kg yesisindo somzimba, u-10mg we-imidacloprid no-2.5mg we-moxidectin, okulingana no-0.1ml walo mkhiqizo. Ngesikhathi sokwelashwa kwe-prophylaxis, kunconywa ukuphatha kanye ngenyanga. Vimbela izinja ekukhotheni.

【Umthelela oseceleni】

(1)Ezimweni ezingazodwana, lo mkhiqizo ungabangela ukungezwani kwendawo, okubangele ukulunywa kwesikhashana, ukunamathela kwezinwele, i-erythema noma ukuhlanza. Lezi zimpawu ziyanyamalala ngaphandle kokwelashwa.

(2) Ngemva kokuphathwa, uma isilwane sikhotha indawo yokusebenzela, kungase kuvele izimpawu zemizwa yesikhashana, njengokujabula, ukuthuthumela, izimpawu zamehlo (abafundi abanwebekayo, i-pupillary reflexes, kanye nenystagmus), ukuphefumula okungavamile, ukuqhiphuka amathe, kanye nezimpawu ezinjengokuhlanza. ; ngezinye izikhathi izinguquko zokuziphatha ezidlulayo ezifana nokungabaza ukuzivocavoca, injabulo, nokulahlekelwa ukudla.

【Izinyathelo zokuzivikela】

(1)Ungayisebenziseli imidlwane engaphansi kwamasonto ayi-7 ubudala. Izinja ezingezwani nalo mkhiqizo akufanele ziwusebenzise. Izinja ezikhulelwe nezincelisayo kufanele zilandele iseluleko sezilwane ngaphambi kokusetshenziswa.

(2)Izinja ezingaphansi kuka-1kg kufanele zilandele iseluleko sikadokotela wezilwane lapho zisebenzisa lo mkhiqizo.

3umkhiqizo ngomlomo.

(4)Izinja ezigulayo nezinja ezinomzimba obuthakathaka kufanele zilandele izeluleko zodokotela bezilwane lapho zizisebenzisa.

(5) Lo mkhiqizo akufanele usetshenziswe kumakati.

6 Ungazithinti noma uphungule izinwele kuze kube yilapho umuthi womile.

(7) Ukuchayeka oku-1 noma okungu-2 kwezinja emanzini ngezikhathi ezithile ngesikhathi sokuphatha ngeke kuthinte kakhulu ukusebenza komuthi. Kodwa-ke, ukusetshenziswa njalo kwe-shampoo ukugeza noma ukucwiliswa emanzini yizinja kungase kube nomthelela ekusebenzeni komuthi.

(8)Gcina izingane zingaxhumani nalo mkhiqizo.

(9)Ungagcini ngaphezu kwama-30℃,futhi ungasebenzisi ngale kosuku lokuphelelwa yisikhathi kwelebula.

(10)Abantu abangezwani nalo mkhiqizo akufanele bawulawule.

(11)Lapho enikeza umuthi, umsebenzisi kufanele agweme ukuthinta isikhumba, amehlo nomlomo walo mkhiqizo, futhi angadli, angaphuzi noma angabhemi; emva kokuphatha, izandla kufanele zigezwe. Uma ichaphaza esikhumbeni ngephutha, geza ngensipho namanzi ngokushesha;uma ifafaza ngephutha emehlweni, yihlanze ngamanzi ngokushesha.

(12)Okwamanje, awukho umuthi othize wokuhlenga walo mkhiqizo; uma ugwinywe ngephutha, amalahle acushwe ngomlomo angasiza ekukhipheni ubuthi.

(13)I-solvent kulo mkhiqizo ingase ingcolise izinto ezifana nesikhumba, izindwangu, ipulasitiki, nezindawo ezipendiwe. Ngaphambi kokuthi indawo yokuphatha yome, vimbela lezi zinto ukuthi zixhumane nesizinda sokuphatha

(14)Ungawuvumeli lo mkhiqizo ungene emanzini angaphezulu.

(15)Izidakamizwa ezingasetshenzisiwe nezinto zokupakisha kufanele zilahlwe ngendlela engenabungozi ngokwezidingo zendawo.

【Ukuhoxiswa  isikhathi】Lutho

【Ukucaciswa】

(1)0.4ml:Imidacloprid 40mg +Moxidectin 10mg

(2)1.0ml:Imidacloprid 100mg+Moxidectin 25mg

(3)2.5ml:Imidacloprid 250mg +Moxidectin 62.5mg

(4)4.0ml:Imidacloprid 400mg+Moxidectin 100mg

 【Isitoreji】

Ivalwe, igcinwe ekamelweni lokushisa.

【Impilo yeshelufu】

3 iminyaka