I-Imidacloprid ne-Moxidectin Spot-on Solutions (Yamakati)

【Izithako】

I-Imidacloprid, i-Moxidectin

【Ukubukeka】

Uketshezi oluphuzi kuya kunsundu.

Isenzo se-Pharmacological:Umuthi we-Antiparasite. I-Pharmacodynamics: I-Imidacloprid isizukulwane esisha sezibulala-zinambuzane ezine-nicotine ezine-chlorine. Inobudlelwane obuphezulu be-postsynaptic nicotinic acetylcholine receptors ohlelweni lwezinzwa olumaphakathi lwezinambuzane, futhi ingavimbela umsebenzi we-acetylcholine, okuholela ekukhubazekeni kwe-parasite nokufa. Isebenza ngempumelelo ngokumelene namazeze amadala namazeze amancane ezigabeni ezihlukahlukene, futhi iphinde ibe nomthelela wokubulala kumazeze amancane endaweni ezungezile.

Indlela yokusebenza ye-moxidectin ifana neye-abamectin ne-ivermectin, futhi inomphumela omuhle we-kiling kuma-parasites angaphakathi nangaphandle, ikakhulukazi ama-nematodes nama-arthropods. Ukukhishwa kwe-butyric acid(GABA) kwandisa amandla ayo okubopha kumamukeli we-postsynaptic, futhi isiteshi se-chloride siyavuleka. I-Moxidectin iphinde ibe nokukhetha kanye nokuhambisana okuphezulu kweziteshi ze-ion ion ze-glutamate mediated chloride, ngaleyo ndlela iphazamise ukudluliswa kwesignali ye-neuromuscular, ukuphumula nokukhubaza ama-parasite, okuholela ekufeni kwama-parasites.

I-interneurons evimbelayo kanye nama-motor neurons ajabulisayo kuma-nematodes yizindawo zayo zokusebenza, kuyilapho kuma-arthropods kuyi-neuromuscular junction. Ukuhlanganiswa kwakho kokubili kunomphumela we-synergistic. I-Pharmacokinet ics: Ngemuva kokuphathwa kokuqala, imidacloprid yasatshalaliswa ngokushesha ebusweni bekati ngalolo suku, futhi yahlala phezu komzimba ngesikhathi sokuphatha izinsuku eziyi-1-2 ngemuva kokuphathwa, ukugcwala kwe-moxidectin ku-plasma kufinyelela ezingeni eliphakeme kakhulu. ,futhi isatshalaliswa emzimbeni wonke phakathi nenyanga eyodwa bese igaywa kancane kancane futhi ikhishwe.

【Ukusetshenziswa nomthamo】

Lo mkhiqizo ukhonjiswe ukuvimbela nokwelashwa kwenge vivofuthiku-vitro izifo ze-parasitic emakati. Lo mkhiqizo ukhonjiswa ukuvimbela nokwelashwa kwezifo zamazeze(Ctenocephalus felis), ukwelashwa kwezifo ze-ear mite(Pruritus auris), ukwelashwa kwezifo ze-nematode zamathumbu (abadala, abantu abadala abangavuthiwe kanye nezibungu ze-L4 zesitejiI-Toxocarria felisfuthiI-Hamnostoma tubuloides), ukuvimbela i-filariasis yenhliziyo (i-L3 kanye ne-L4 yesiteji se-heartworms). Futhi ingasiza ekwelapheni i-allergic dermatitis ebangelwa amazeze.

【Ukusetshenziswa nomthamo】

Ukusetshenziswa kwangaphandle. Umthamo owodwa, ikati ngesisindo somzimba esingu-1kg, 10mg imidacloprid 1mg moxidectin, okulingana no-0.1ml walo mkhiqizo. Ngesikhathi se-prophylaxis noma ukwelashwa, kunconywa ukuphatha kanye ngenyanga. Ukuze uvimbele ukukhothwa, faka kuphela esikhumbeni esingemuva kwekhanda nentamo yekati.

【Umphumela omude】

(1)Ezimweni ezingazodwana, lo mkhiqizo ungase ubangele ukungezwani kwendawo, okubangele ukulunywa kwesikhashana, ukunamathela kwezinwele, i-erythema noma ukuhlanza.Lezi zimpawu ziyanyamalala ngaphandle kokwelashwa.

(2) Ngemva kokuphathwa, uma isilwane sikhotha indawo yokuqondisa, izimpawu zemizwa yesikhashana zingase zivele ngezikhathi ezithile, njengokujabula, ukuthuthumela, izimpawu zamehlo (abafundi abanwebekayo, i-pupillary reflexes, nenystagmus), ukuphefumula okungavamile, ukuqhiphuka amathe, kanye nezimpawu ezinjengokuhlanza. ;izinguquko ezishintshayo zokuziphatha kwesinye isikhathi njengokungathandi ukujima, ukujabula, kanye nokuphelelwa ukudla.

【Izinyathelo zokuzivikela】

(1)Ungasebenzisi amakati angaphansi kwamasonto ayi-9 ubudala. Ungasebenzisi kumakati angezwani nalo mkhiqizo. Izinja ezikhulelwe nezincelisayo kufanele zilandele iseluleko sezilwane ngaphambi kokusetshenziswa.

(2)Amakati angaphansi kwe-1kg kufanele alandele iseluleko sikadokotela wezilwane lapho esebenzisa lo mkhiqizo.

3

(4)Amakati agulayo namakati anomzimba obuthakathaka kufanele alandele izeluleko zodokotela bezilwane lapho ewasebenzisa.

(5) Lo mkhiqizo akufanele usetshenziselwe izinja.

6 Ungazithinti noma uphungule izinwele kuze kube yilapho umuthi womile.

(7) Ukuchayeka oku-1 noma okungu-2 kwamakati emanzini ngezikhathi ezithile ngesikhathi sokuphatha ngeke kuthinte kakhulu ukusebenza komuthi. Kodwa-ke, amakati avame ukugeza nge-shampoo noma acwiliswe emanzini angase abe nomthelela ekusebenzeni komuthi.

(8)Gcina izingane zingaxhumani nalo mkhiqizo.

(9)Ungagcini ngaphezu kuka-30℃, futhi ungasebenzisi ngaphezu kosuku lokuphelelwa yisikhathi kwelebula.

(10)Abantu abangezwani nalo mkhiqizo akufanele bawulawule.

(11)Lapho enikeza umuthi, umsebenzisi kufanele agweme ukuthinta isikhumba, amehlo kanye nomlomo walo mkhiqizo, futhi angadli, angaphuzi noma abheme; ngemva kokuphatha, izandla kufanele zigezwe. Uma kunjalo

echaphaza esikhumbeni ngephutha, sigeze ngensipho namanzi ngokushesha;uma sichaphazela emehlweni ngephutha, sigeze ngamanzi ngokushesha. Uma izimpawu zingathuthuki, sicela uthintane nodokotela

imiyalelo.

(12)Okwamanje, awukho umuthi othize wokuhlenga walo mkhiqizo;uma ugwinywe ngephutha, amalahle acushwe ngomlomo angasiza ekukhipheni ubuthi.

(13)I-solvent kulo mkhiqizo ingase ingcolise izinto ezifana nesikhumba, izindwangu, ipulasitiki, nezindawo ezipendiwe. Ngaphambi kokuthi indawo yokuphatha yome, vimbela lezi zinto ukuthi zixhumane nesizinda sokuphatha.

(14)Ungawuvumeli lo mkhiqizo ungene emanzini angaphezulu.

(15)Izidakamizwa ezingasetshenzisiwe nezinto zokupakisha kufanele zilahlwe ngendlela engenabungozi ngokwezidingo zendawo.

【Isikhathi sokuhoxa】Lutho.

【Imininingwane】

(1)0.4ml:Imidacloprid 40mg+Moxidectin 4mg

(2)0.8ml:Imidacloprid 80mg +Moxidectin 8mg

【Isitoreji】Ivalwe, igcinwe ekamelweni lokushisa.

【Impilo yeshelufu】3 iminyaka.